Stable DOPG/Glycyrrhizin Vesicles with a Wide Range of Mixing Ratios: Structure and Stability as Seen by Scattering Experiments and Cryo-TEM
نویسندگان
چکیده
Phosphatidylglycerols represent a large share of the lipids in plasmamembrane procaryotes. Therefore, this study investigates role charged plasma membrane with respect to interaction antiviral saponin glycyrrhizin such membranes. Glycyrrhizin is natural triterpenic-based surfactant found licorice. Vesicles made 1,2-dioleoyl-sn-glycero-3-phospho-rac-(1’-glycerol) (DOPG)/glycyrrhizin are characterized by small-angle scattering neutrons and X-rays (SANS SAXS). Small-angle data first evaluated model-independent modified Kratky–Porod method afterwards fitted model describing shape small unilamellar vesicles (SUV) an internal head-tail contrast. Complete miscibility DOPG was revealed even at ratio lipid:saponin 1:1. Additional information about chain-chain correlation distance lipid/saponin mixtures SUV structures obtained from wide-angle X-ray (WAXS).
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ژورنال
عنوان ژورنال: Molecules
سال: 2021
ISSN: ['1420-3049']
DOI: https://doi.org/10.3390/molecules26164959